A portion of Highway 101 in San Francisco will shut down over two weekends in September as part of an ongoing pavement repair project, Caltrans said. Here’s what to know about the project, when the shutdowns will happen and detour information. When will Highway 101 shut down in San Francisco ? The weekend shutdowns of northbound Highway 101 (Hospital Curve) will be held: 11 p.m. Friday, Sept. 4 through 6 a.m. Monday, Sept. 7 (Labor Day weekend) 11 p.m. Friday, Sept. 18 through 6 a.m. Monday, Sept. 21 What part of Highway 101 will be impacted by the pavement repair project? Caltrans will close all northbound Highway 101 lanes between Cesar Chavez and 10th streets. All southbound lanes will remain open. Detour information during Highway 101 closure in San Francisco Interstate 280 will be the main alternative during the northbound Hwy. 101 closure. Caltrans said I‑280 northbound is suggested for travel toward downtown San Francisco or the Bay Bridge. Public transportation is also highly encouraged to bypass congestion and avoid work‑zone delays. Why is a pavement repair project needed on Highway 101? The weekend closures along northbound Highway 101 in San Francisco is needed to complete pavement repair as part of a Hospital Curve rehabilitation project, Caltrans said. The project began in Fall 2025. Bay Area Aug 21 A closer look: Major construction projects on Carquinez Bridge and Hwy. 101 Transportation Jul 20 Caltrans releases Bay Area transit plan to improve access on state highways ...read more read less